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    Targeted Libraries

    The libraries contain in-stock compounds with pSEA1 value greater than 50. All libraries are available as a full or a cherry-picked set. We supply the compounds as solids, DMSO solutions, or dry films in vials or 96, 384 well plates.
    List of proteins (sorted by the human gene names):

    ACE Angiotensin-converting enzyme sdf
    ACE2 Angiotensin-converting enzyme 2 sdf
    ACKR3 Atypical chemokine receptor 3 sdf
    ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) sdf
    AGTR2 Angiotensin II type-2 receptor sdf
    AKR1C3 Aldo-keto reductase family 1 member C3 sdf
    BRCA1 Breast cancer type 1 susceptibility protein sdf
    CAPN1 Calcium-activated neutral proteinase 1 sdf
    CASP3 Caspase-3 sdf
    CASP7 Caspase-7 sdf
    CCR2 C-C chemokine receptor type 2 (C-C CKR-2) sdf
    CCR3 C-C chemokine receptor type 3 (C-C CKR-3) sdf
    CCR5 C-C chemokine receptor type 5 (C-C CKR-5) sdf
    CCR8 C-C chemokine receptor type 8 (C-C CKR-8) sdf
    CFTR Cystic fibrosis transmembrane conductance regulator sdf
    CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 sdf
    CPA1 Carboxypeptidase A1 sdf
    CPT1A Carnitine palmitoyltransferase 1A sdf
    CPT2 Carnitine palmitoyltransferase I sdf
    CTSA Cathepsin A sdf
    DPP7 Dipeptidyl peptidase 7 sdf
    ECE1 Endothelin-converting enzyme 1 sdf
    ELANE Elastase-2 sdf
    ETHR Thyroid hormone receptor beta sdf
    FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A sdf
    FPR1 N-formyl peptide receptor sdf
    HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 sdf
    HTR1A 5-hydroxytryptamine receptor 1A sdf
    INHA Inhibin alpha chain sdf
    ITGA4 Integrin alpha-4 sdf
    KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 sdf
    LGMN Legumain sdf
    LIPG Endothelial lipase sdf
    MBTPS1 Membrane-bound transcription factor site-1 protease sdf
    MLNR Motilin receptor G-protein coupled receptor 38) sdf
    MME Neprilysin sdf
    NOS2 Nanos homolog 2 (NOS-2) sdf
    OPRD1 Delta-type opioid receptor (D-OR-1) (DOR-1) sdf
    P2RX7 P2X purinoceptor 7 (P2X7) sdf
    PREP Prolyl endopeptidase sdf
    RBP4 Retinol-binding protein 4 sdf
    SFRP1 Secreted frizzled-related protein 1 sdf
    SIGMAR1 Sigma non-opioid intracellular receptor 1 sdf
    SLC6A1 Sodium- and chloride-dependent GABA transporter 1 sdf
    ST14 Suppressor of tumorigenicity 14 protein sdf
    TIMP3 Tissue inhibitor of metalloproteinases 3 sdf
    TMPRSS11D Transmembrane protease serine 11D sdf
    TRPC6 Short transient receptor potential channel 6 sdf
    WNT3 Proto-oncogene Wnt-3 sdf
    XIAP E3 ubiquitin-protein ligase XIAP sdf
    1. Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007)

    The following focused and targeted libraries are available upon request:

    Anti-cancer covalent kinase-oriented set
    Anti-cancer kinase library
    Appoptotic library
    Aquaporins targeted library
    Caspase focused library
    Frequent hitters library (PAINS)
    Immuno-oncology
    Ion channel modulators
    Matrix metalloproteinases targeted library
    PDE10 + PDE5/3 targeted library
    PPI targeted library
    Protease inhibitors library
    REDOX library
    Signaling pathways targeted library

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