Focused Libraries

There is a direct relation between the quality of a screening library and the success of a drug discovery project. Lead-like compounds are an ideal starting point for such purpose allowing final compounds to remain in drug-like space. Our library contains 125,569 lead-like molecules which have been cautiously chosen from FCH group screening compound collection.

Our representative acids have a potential use as peptidomimetics (e.g. RGD), ligands for specific GPCRs (e.g. S1P), Bile receptors in the gut, etc. The set contains 31,283 unique carboxylic acids with lead-like profiles.

Our representative amines have a perspective in the modulation of ion channels GPCRs. The set contains 27,604 unique primary and secondary amines with lead-like profiles.

A fast growth of peptidomimetics has encouraged us to create a representative set of unnatural amino acids. The set contains 668 compounds with lead-like profiles and is a good starting point for a research where unnatural amino acids might be molecules of interest.

The set contains 2,256 compounds that possess a lead-like profile as well as a rigid spirocyclic moiety.

Diversity libraries

Two diverse sets which represent our screening compound library and cover broad chemical space